教师信息

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  • 姜延龙
  • 性别

  • 出生年月

    1981/12/1
  • 所在单位

    动物医学院
  • 专业

    预防兽医学
  • 电话

  • Email

    yanlong.jiang@jlau.edu.cn

个人情况综述

       东北农业大学博士,美国亚利桑那州立大学博士后,博士生导师,国家级青年人才。多年来一直从事新型细菌性口服疫苗及微生态制剂研究,发表学术论文100余篇,其中SCI收录期刊80余篇,以第一作者或通讯作者在Appl Environ Microbiol、 Infection and Immunity等SCI期刊发表文章18篇,研究成果被包括Nature Reviews Microbiology, Plos Pathogens, Journal of Immunity在内的多篇期刊引用报道超600次,参编英文专著2部,获批专利11项。先后主持国家自然科学青年基金、面上项目、国家重点研发计划项目子课题、吉林省科技厅面上项目、吉林省教育厅十三五科技规划重点项目等8项课题。现担任中国微生物学会兽医微生物学分会青年委员,中国兽医协会团体标准技术委员会家禽疾病诊疗分委会委员。

学习工作简历

教育经历

1999/09-2003/07,  东北农业大学,生命科学理科基地班,本科/学士;

2003/09-2006/07,东北农业大学,预防兽医学,硕士;

2006/09-2009/07,东北农业大学,预防兽医学,博士;

工作经历:

2009/08-2010/01, 哈药集团生物技术有限公司,研发;

2010/03-2014/09,美国亚利桑那州立大学,生物设计研究所,传染病与疫苗中心,博士后;合作导师:美国科学院院士Roy Curtiss III,。

2015/09-至今,威斯尼斯人wns888入口中国威斯尼斯人wns888入口中国。

教学工作

兽医学留学生: 微生物与免疫学

硕士研究生:高级分子生物学、基因工程

本科生:兽医微生物学、动物微生物学、现代生物技术实验

主要科研方向

新功能型微生态制剂研制,主要包括以乳酸菌及减毒沙门氏菌为载体的口服疫苗研究。

主要科研项目

1.   国家自然科学基金面上项目“基于新型微环DNA技术平台CRIM的H9N2禽流感广谱性原位靶向纳米疫苗激活特异性细胞免疫机制研究”,2021-2024,在研;

2.   吉林省科技厅面上项目,延迟裂解-侵入型植物乳杆菌递送 H9N2 亚型禽流感口服纳米疫苗研究,2022-2025,在研,主持

3.   吉林省教育厅“十三五”科学技术项目一般项目“新型高效基因VII型新城疫病毒CRIM口服疫苗创制”,2020-2021,结题,主持;

4.   “国家重点研发计划项目”之“畜禽重要胞内寄生原虫的寄生与免疫机制研究”子课题,2017-2020,结题;

5.   国家自然科学基金青年基金项目“延迟裂解型沙门菌递送新城疫mcDNA疫苗的免疫效应与机制研究,2017-2019,结题;

6.   威斯尼斯人wns888入口中国首批青年拔尖人才支持计划课题,2016-2018,结题;

7.   吉林省教育厅“十三五”科学技术项目重点项目“新功能侵入型乳酸菌疫苗的构建及其分子免疫机制研究”,2017-2018,结题

主要科研成果

免疫增强型抗感染微生态制剂创制及在健康养殖中的应用,吉林省科学技术奖,一等奖,6/15,2018年11。

发表文章

1. In Vivo Production of HN Protein Increases the Protection Rates of a Minicircle DNA Vaccine against Genotype VII Newcastle Disease Virus,Zhannan Wang, Xiaohan Zhao, Ying Wang, Chao Sun, Ming Sun, Xingyun Gao, Futing Jia, Chenxin Shan, Guilian

Yang, Jianzhong Wang, Haibin Huang, Chunwei Shi, Wentao Yang, Aidong Qian, Chunfeng Wang*, Yanlong Jiang*. Vaccines (Basel). 2021 Jul 2;9(7):723.

2. Dendritic cells targeting Lactobacillus plantarum strain NC8 with surface  displayed single chain variable fragment of CD11c induce antigen specific protective cellular immune response. Jing Liu, Guilian Yang, Haibin Huang, Chunwei Shi, Xing Gao, Wentao Yang, Zan Zhang, Yang Liu, Ke Xu, Jianzhong Wang, Yuanhuan Kang, Yanlong Jiang*, Chunfeng Wang*. Infection and Immunity, , 2020, Feb;88(2): e00759-19.

3. Yanlong Jiang, Xing Gao, Ke Xu, Jianzhong Wang, Haibin Huang, Chunwei Shi, Wentao Yang, Yuanhuan Kang, Roy Curtiss, Guilian Yang*, Chunfeng Wang*. A novel Cre recombinase-mediated in vivo minicircle DNA (CRIM) vaccine provides partial protection against Newcastle disease virus, Applied and Environmental Microbiology, 2019, Jul 1;85(14). pii: e00407-19. Spotlight研究)

4. Jing Liu, Guilian Yang, Xing Gao, Zan Zhang, Yang Liu, Qiong Liu, Jean-Marc Chatel, Yanlong Jiang*, Chunfeng Wang*. Recombinant invasive Lactobacillus plantarum expressing Fibronectin Binding Protein A induce specific humoral immune response by stimulating differentiation of dendritic cells. Benef Microbes, 2019,  May 28;10(5):589-604.

5. Xing Gao, Ke Xu, Guilian Yang, Chunwei Shi, Wentao Yang, Jing Liu, Qiong Liu, Jianzhong Wang, Haibin Huang, Yuanhuan Kang, Yanlong Jiang*, Chunfeng Wang*. Construction of a novel DNA vaccine candidate targeting F gene of genotype VII Newcastle disease virus and chicken IL-18 delivered by Salmonella. J App Microbe,  2019, 126(5):1362-1372.6

6. Liu J, Yang G, Gao X, Zhang Z, Liu Y, Yang X, Shi C, Liu Q, Jiang Y*, Wang C*. Immunomodulatory properties of Lactobacillus plantarum NC8 expressing an anti-CD11c single-chain Fv fragment, J Microbiol Biotechnol, 2019 ; 29(1): 160~170

7. Wilde S#, Jiang Y#, Tafoya AM, Horsman J, Yousif M, Vazquez LA, Roland KL*. Salmonella-vectored vaccine delivering three Clostridium perfringens antigens protects poultry against necrotic enteritis. PLoS One, 2019 Feb 12;14(2):e0197721.

8. Yanlong Jiang, Guilian Yang, Qi Wang, Zhannan Wang, Wentao Yang, Wei Gu, Chunwei Shi, Jianzhong Wang, Haibin Huang, Chunfeng Wang*. Molecular mechanisms underlying protection against H9N2 influenza virus challenge in mice by recombinant Lactobacillus plantarum with surface displayed HA2-LTB. J Biotechnol, 2017 Oct 10;259:6-14.

9.  Yanlong Jiang, Liping Ye, Yulin Cui, Guilian Yang, Wentao Yang, Jianzhong Wang, Jingtao Hu, Wei Gu, Chunwei Shi, Haibin Huang, Chunfeng Wang*. Effects of Lactobacillus rhamnosus GG on the maturation and differentiation of dendritic cells in rotavirus-infected mice. Benef Microbes2017 Aug 24;8(4):645-656.

10. G. Yang#, Y. Jiang#, P. Tong, C. Li, W. Yang, J. Hu, L. Ye, W. Gu, C. Shi, B. Shan, C. Wang*.Alleviation of enterotoxigenic Escherichia coli challenge by recombinant Lactobacillus plantarum expressing a FaeG- and DC-targeting peptide fusion protein. Benef Microbes, 2017, 8(3):379-391

11. Jiang Y#, Yang G#, Meng F, Yang W, Hu J, Ye L1, Shi C, Wang C*. Immunological mechanisms involved in probiotics mediated protection against Citrobacter rodentium induced colitis. Benef Microbes, 2016 Jun;7(3):397-407.

12. Jiang Y#, Hu J#, Guo Y, Yang W, Ye L, Shi C, Liu Y, Yang G, Wang C*. Construction and immunological evaluation of recombinant Lactobacillus plantarum expressing HN of Newcastle disease virus and DC- targeting peptide fusion protein. J Biotechnol, 2015 Dec 20;216:82-9. 

13. Jiang Y, Mo H, Willingham C, Wang S, Park J Y, Kong W, Roland K L, Curtiss R, 3rd*. Protection Against Necrotic Enteritis in Broiler Chickens by Regulated Delayed Lysis Salmonella Vaccines. Avian Diseases, 2015, 59(4): 475-485.

14. Guilian Yang,# Yanlong Jiang,# Wentao Yang, Fang Du, Yunbao Yao, Chunwei Shi, and Chunfeng Wang*. Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide. Microbial Cell Factories, 2015,14:202

15. Yanlong Jiang, Qingke Kong, Kenneth Roland, Roy Curtiss III*. Membrane vesicles of Clostridium perfringens Type A strains induce innate and adaptive immunity. International Journal of Medical Microbiology, 2014, May;304(3-4):431-43

16. Yanlong Jiang, Qingke Kong, Kenneth Roland, Roy Curtiss III*. Multiple inhibition effects of E.coli Nissle strain on Clostridium perfringens. FEMS Pathogens and disease , 2014, Apr;70(3):390-400.

17.Yanlong Jiang, H. Liu , P. Liu, and X. Kong*. Plasmids driven rescue system for Newcastle disease virus V4 strain. Molecular Biology Reports, 2009,36:1909-1914

教材及专著

Mucosal Vaccines: Innovations for Preventing Infectious Diseases ,第二版,参编, ELSEVIER出版,ISBN: 978-0-12-811924-2,2020, Pages 383-399,章节题目:Attenuated Salmonella for Oral Immunization;

Methods in Molecular Biology丛书,DNA Vaccines: Methods and Protocols,参编,2021;2197:3-12,Springer出版,章节题目:A Novel Cre Recombinase-Mediated In Vivo Minicircle (CRIM) DNA Vaccine Platform for Veterinary Application

获奖信息

免疫增强型抗感染微生态制剂创制及在健康养殖中的应用,吉林省科学技术奖,一等奖,6/15,2018年11。

社会兼职

中国微生物学会兽医微生物学分会青年委员,中国兽医协会团体标准技术委员会家禽疾病诊疗分委会委员。

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